Journal: Journal of Pharmaceutical Analysis
Article Title: Effects and translatomics characteristics of a small-molecule inhibitor of METTL3 against non-small cell lung cancer
doi: 10.1016/j.jpha.2023.04.009
Figure Lengend Snippet: In vivo effects and regulation of STM2457 on programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC). (A) The modeling and drug administration scheme of a pulmonary metastasis mouse model. (B) In the lung sections of a pulmonary metastasis mouse model, the effect of STM2457 on NSCLC progression and the regulation of STM2457 on the expression of both methyltransferase-like 3 (METTL3) and PD-L1 in vivo were evaluated using hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC) staining, respectively. HP: hydroxypropyl.
Article Snippet: In in vivo experiments, STM2457 was dissolved in a 20% ( m / V ) 2-hydroxypropyl-beta-cyclodextrin (Glpbio, Montclair, CA, USA) vehicle as the working solution with a concentration of 5 mg/mL.
Techniques: In Vivo, Expressing, Staining, Immunohistochemistry